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I've seen bits and pieces of things from the remainder of the early '80s on Eddie's tapes (can't wait to see the whole storylines, hopefully, someday), but starting in 1980, Mac got hurt or suffered serious injuries or medical conditions a lot:
[spoiler]1979-80: Janice Frame poisons Mac and he nearly dies.
1981: Mac is shot in the chest by loudmouth Lenny the Hitman, who was aiming for Sandy.
1984: On a business trip to British Columbia, Mac's plane crashes; he's the only survivor and is found half-frozen in the Canadian wilderness.
1984: Several months after surviving the plane crash, Mac suffers a stroke, which sends him into physical and speech therapy to learn to walk and talk again.
I never realized until now just how much they put Mac through from a medical/physical standpoint over those 4-5 years (especially 1984--talk about six of one and half a dozen of the other!).